HDAC-IN-63_product_DataBase

CAS: 2920046-95-1 F: C25H26Cl2N6O3 W: 529.42

HDAC-IN-63 (Compound 63) is a dual FLT3/HDAC inhibitor (IC50: 0.844 and 30.0 nM for FLT3 and HDAC1 respectively). HDAC-I

This product is for research use only, not for human use. We do not sell to patients.

Bioactivity	HDAC-IN-63 (Compound 63) is a dual FLT3/HDAC inhibitor (IC50: 0.844 and 30.0 nM for FLT3 and HDAC1 respectively). HDAC-IN-63 inhibits MV4-11 cell proliferation (IC50: 92 nM. HDAC-IN-63 induces apoptosis and arrests cell cycle in MV4-11 cells. HDAC-IN-63 can be used for research of acute myeloid leukemia (AML)[1].
Target	0.844 and 30.0 nM for FLT3 and HDAC1
Name	HDAC-IN-63
CAS	2920046-95-1
Formula	C25H26Cl2N6O3
Molar Mass	529.42
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Wang Z, et al. Rational discovery of dual FLT3/HDAC inhibitors as a potential AML therapy. Eur J Med Chem. 2023 Aug 28;260:115759.

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