| Bioactivity | HDAC-IN-51 is a potent histone deacetylase (HDAC) inhibitor with IC50 values of 0.32, 0.353, 0.431, 0.515, and 85.4 μM for HDAC10, HDAC1, HDAC2, HDAC3 and HDAC11, respectively. HDAC-IN-51 induces cell cycle arrest and apoptosis, modulating cell cycle-/apoptosis-related miRNAs expression. HDAC-IN-51 can be used in research of cancer[1]. |
| Invitro | HDAC-IN-51 (compound 8d; 1 nM-10 μM; 48 h) 具有抗增殖活性，对 K562、HCT116 和 A549 细胞的 IC50 值分别为 0.54、0.56 和 1.35 μM [1].HDAC-IN-51 (1 and 5 μM; 24 and 48 h; U937 白血病细胞) 使细胞周期停滞在 G1 期[1]。HDAC-IN-51 (1 and 5 μM; 48 h; U937 细胞) 诱导细胞凋亡并下调具有抗细胞凋亡活性的 miRNA（miR-17-5p、miR-18-5p、miR-19b-3p、miR-20a- 5p 和 miR-21-5p)[1]。HDAC-IN-51 (1 and 5 μM; 48 h; U937 细胞) 增加 p21、BAX 和 BAK 的 mRNA 表达，下调细胞周期蛋白 D1 和 BCL-2[1]。 Cell Viability Assay[1] Cell Line: |
| Name | HDAC-IN-51 |
| Formula | C27H24N4O2 |
| Molar Mass | 436.51 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |