HDAC-IN-50

CAS: 2653339-26-3 F: C31H41N7O4 W: 575.70

HDAC-IN-50 is a potent and orally active FGFR and HDAC dual inhibitor with IC50 values of 0.18, 1.2, 0.46, 1.4, 1.3, 1.6

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Bioactivity	HDAC-IN-50 is a potent and orally active FGFR and HDAC dual inhibitor with IC50 values of 0.18, 1.2, 0.46, 1.4, 1.3, 1.6, 2.6, 13 nM for FGFR1, FGFR2, FGFR3, FGFR4, HDAC1, HDAC2, HDAC6, HDAC8, respectively. HDAC-IN-50 induces Apoptosis and cell cycle arrest at G0/G1 phase. HDAC-IN-50 decreases the expression of pFGFR1, pERK, pSTAT3. HDAC-IN-50 shows anti-tumor activity[1].
Invitro	HDAC-IN-50 (compound 10e) (0.1, 1, 10, 100 nM; 12-84 h) 以时间和剂量依赖性方式诱导细胞凋亡和细胞周期停滞在 G0/G1 期[1]。HDAC-IN-50 (0, 1.25, 2.5, 5 µM for HCT116 cells, 0, 1, 10, 100 nM for SNU-16 cells; 36 h) 以剂量依赖性方式降低 pFGFR1、pERK、pSTAT3 的表达 [1]。 Cell Proliferation Assay[1] Cell Line:
Name	HDAC-IN-50
CAS	2653339-26-3
Formula	C31H41N7O4
Molar Mass	575.70
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.

Antitumor agent-83

Ibuprofen-d3 (sodium)