HDAC-IN-42

CAS: 2454024-18-9 F: C20H15NO7 W: 381.34

HDAC-IN-42 (compound 14f) is a potent and selective HDAC inhibitor with IC50 values of 0.19 and 4.98 µM for HDAC1 and H

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Bioactivity	HDAC-IN-42 (compound 14f) is a potent and selective HDAC inhibitor with IC50 values of 0.19 and 4.98 µM for HDAC1 and HDAC6, respectively. HDAC-IN-42 shows anticancer and anti-proliferative activity. HDAC-IN-42 induces apoptosis and cell cycle arrest at G2/M phase[1].
Invitro	HDAC-IN-42 (compound 14f) shows anti-proliferative activity with C50s of 9.56, 13.32, 10.46, 6.91 µM for MCF-7, HCT-116, HepG2, Hela cells, respectively[1].HDAC-IN-42 (1, 5, 10 µM; 24 h) reduces the colony formation and increases the expression of histone H3 and α-tubulin in HeLa cells[1].HDAC-IN-42 (1, 5, 10 µM; 48 h) induces apoptosis and cell cycle arrest at G2/M phase[1].
Name	HDAC-IN-42
CAS	2454024-18-9
Formula	C20H15NO7
Molar Mass	381.34
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.

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