| Bioactivity | HCV-IN-40 (Compound 18c) is a potent, orally active hepatitis C virus (HCV) nucleoside inhibitor with EC50 values of 0.259, 0.434 and 0.069 μM against GT1a, GT1b and GT1b CES1 replicons[1]. |
| Target | EC50: 0.069 μM (GT1b CES1), 0.259 μM (GT1a), 0.434 μM (GT1b) |
| In Vivo | HCV-IN-40 (Compound 18c) (1 mg/kg) provides very high nucleotide triphosphate (TP) in dog liver[1]. |
| Name | HCV-IN-40 |
| CAS | 2087916-66-1 |
| Formula | C21H26BrFN3O9P |
| Molar Mass | 594.32 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Chris Krueger A, et al. Synthesis and evaluation of 2'-dihalo ribonucleotide prodrugs with activity against hepatitis C virus. Bioorg Med Chem. 2020 Jan 1;28(1):115208. |
HCV-IN-40
CAS: 2087916-66-1 F: C21H26BrFN3O9P W: 594.32
HCV-IN-40 (Compound 18c) is a potent, orally active hepatitis C virus (HCV) nucleoside inhibitor with EC50 values of 0.2
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