Bioactivity | HCTZ-CH2-HCTZ is an isomer of HCTZ (HY-B0252). Hydrochlorothiazide (HCTZ), an orally active diuretic agent of the thiazide class, inhibits transforming TGF-β/Smad signaling pathway[1][2]. |
CAS | 402824-96-8 |
Formula | C15H16Cl2N6O8S4 |
Molar Mass | 607.49 |
Transport | Room temperature in continental US; may vary elsewhere. |
Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Reference | [1]. X Fang, et al. Purification and identification of an impurity in bulk hydrochlorothiazide. J Pharm Sci. 2001 Nov;90(11):1800-9. [2]. Duarte, J.D. and R.M. Cooper-DeHoff, Mechanisms for blood pressure lowering and metabolic effects of thiazide and thiazide-like diuretics. Expert Rev Cardiovasc Ther, 2010. 8(6): p. 793-802. |