| Bioactivity | HC-5404-Fu is a PERK inhibitor with an antitumor activity. HC-5404-Fu inhibits endoplasmic reticulum stress response signalling. HC-5404-Fu sensitizes renal cell carcinoma cells to vascular endothelial growth factor (VEGF) receptor tyrosine kinase inhibitors (TKIs). HC-5404-Fu is promising for research of renal cell carcinoma, gastric cancer, metastatic breast cancer, small cell lung cancer, and other solid tumors[1][2][3]. |
| CAS | 3034479-99-4 |
| Formula | C24H24F2N4O3.1/2C4H4O4 |
| Molar Mass | 512.51 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Lines CL, et al. The integrated stress response in cancer progression: a force for plasticity and resistance. Front Oncol. 2023 Aug 3;13:1206561. [2]. Al-Rawi DH, et al. Targeting chromosomal instability in patients with cancer. Nat Rev Clin Oncol. 2024 Sep;21(9):645-659. [3]. Al Azzani M, et al. Phytochemical-mediated modulation of autophagy and endoplasmic reticulum stress as a cancer therapeutic approach. Phytother Res. 2024 Jul 3. |
HC-5404-Fu
CAS: 3034479-99-4 F: C24H24F2N4O3.1/2C4H4O4 W: 512.51
HC-5404-Fu is a PERK inhibitor with an antitumor activity. HC-5404-Fu inhibits endoplasmic reticulum stress response sig
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