| Bioactivity | HBpep-SA is a cell membrane-permeable peptide condensate that phase separates to form stable droplets at pH values below 6.5. HBpep-SA is able to directly and efficiently deliver a variety of macromolecules, ranging from therapeutic peptides as small as 726 Da to large enzymes as large as 430 kDa, and the loaded condensates remain stable under near-physiological and serum conditions until internalized by cells. HBpep-SA can be used for intracellular delivery of large numbers of macromolecules and as a vector for mRNA-based vaccines[1]. |
| Name | HBpep-SA |
| Sequence | Gly-His-Gly-Val-Tyr-Gly-His-Gly-Val-Tyr-Gly-His-Gly-Pro-Tyr-{Lys(NHS-SS-Ac)}-Gly-His-Gly-Pro-Tyr-Gly-His-Gly-Leu-Tyr-Trp |
| Shortening | GHGVYGHGVYGHGPY-{Lys(NHS-SS-Ac)}-GHGPYGHGLYW |
| Formula | C145H187N39O37S2 |
| Molar Mass | 3132.41 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Sun Y, et al. Phase-separating peptides for direct cytosolic delivery and redox-activated release of macromolecular therapeutics. Nat Chem. 2022 Mar;14(3):274-283. |