| Bioactivity | HBpep-SA is a cell membrane-permeable peptide condensate that phase separates to form stable droplets at pH values below 6.5. HBpep-SA is able to directly and efficiently deliver a variety of macromolecules, ranging from therapeutic peptides as small as 726 Da to large enzymes as large as 430 kDa, and the loaded condensates remain stable under near-physiological and serum conditions until internalized by cells. HBpep-SA can be used for intracellular delivery of large numbers of macromolecules and as a vector for mRNA-based vaccines[1]. | ||||||
| Sequence | Gly-His-Gly-Val-Tyr-Gly-His-Gly-Val-Tyr-Gly-His-Gly-Pro-Tyr-{Lys(NHS-SS-Ac)}-Gly-His-Gly-Pro-Tyr-Gly-His-Gly-Leu-Tyr-Trp | ||||||
| Shortening | GHGVYGHGVYGHGPY-{Lys(NHS-SS-Ac)}-GHGPYGHGLYW | ||||||
| Formula | C145H187N39O37S2.xC2HF3O2 | ||||||
| Molar Mass | 3132.41 (free base) | ||||||
| Appearance | 固体 | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Sealed storage, away from moisture
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
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| Reference | [1]. Sun Y, et al. Phase-separating peptides for direct cytosolic delivery and redox-activated release of macromolecular therapeutics. Nat Chem. 2022 Mar;14(3):274-283. |
HBpep-SA TFA
CAS: F: C145H187N39O37S2.xC2HF3O2 W: 3132.41 (free base)
HBpep-SA is a cell membrane-permeable peptide condensate that phase separates to form stable droplets at pH values
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