| Bioactivity | HBV-IN-29 (ex8), a flavone derivative, is a potent covalently closed circular DNA (cccDNA) inhibitor. cccDNA serves as the template for viral RNA transcription and subsequent viral DNA generation. HBV-IN-29 has the potential for the research of HBV infection[1]. |
| Invitro | HBV-IN-29 (ex8; 24 h) 在 HepDES19 细胞中抑制 HBeAg 水平和细胞活力，IC50 值为 1.34 μM。HepDES19 是产生 cccDNA 的细胞系[1]。HBV-IN-29 (5 days) 以剂量依赖性方式降低 HepDES19 细胞中的 cccDNA 水平[1]。HBV-IN-29 (9 天; 原代人肝细胞 (PHH)) 具有抗 HBV 作用并抑制 HBeAg，IC50 值为 0.12 μM[1]。 |
| Name | HBV-IN-29 |
| CAS | 2413192-59-1 |
| Formula | C22H19ClO6 |
| Molar Mass | 414.84 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Song F, et, al. Flavone compounds for the treatment and prophylaxis of hepatitis b virus disease. WO2020053249. |
HBV-IN-29
CAS: 2413192-59-1 F: C22H19ClO6 W: 414.84
HBV-IN-29 (ex8), a flavone derivative, is a potent covalently closed circular DNA (cccDNA) inhibitor. cccDNA serves as t
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