| Bioactivity | H4 Receptor antagonist 1 is a potent and selective histamine H4 receptor inverse agonist, with an IC50 of 19 nM. | ||||||||||||
| Invitro | H4 Receptor antagonist 1 is a potent and selective histamine H4 receptor inverse agonist, with an IC50 of 19 nM[1]. | ||||||||||||
| In Vivo | H4 Receptor antagonist 1 indicates that metabolic stability in rat microsomes is very low with only 1% parent compound remaining after 10 min incubation[1]. | ||||||||||||
| Name | H4 Receptor antagonist 1 | ||||||||||||
| CAS | 848217-00-5 | ||||||||||||
| Formula | C16H17ClN4O | ||||||||||||
| Molar Mass | 316.79 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Cramp S, et al. Identification and hit-to-lead exploration of a novel series of histamine H4 receptor inverse agonists. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2516-9. |
H4 Receptor antagonist 1
CAS: 848217-00-5 F: C16H17ClN4O W: 316.79
H4 Receptor antagonist 1 is a potent and selective histamine H4 receptor inverse agonist, with an IC50 of 19 nM.
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