| Bioactivity | H3B-968 is a potent inhibitor of Werner syndrome protein (WRN) (IC50=~10 nM)，which acts function as helicase，ATPase，and exonuclease. WRN exhibits synthetic lethal activity in cancer research. However，H3B-968 inhibits WRN helicase activity，competitively with ATP[1]. |
| Target | Werner syndrome protein (WRN) |
| Name | H3B-968 |
| CAS | 2912294-90-5 |
| Formula | C22H18F6N4O4S |
| Molar Mass | 548.46 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Parker MJ, et al. Identification of 2-Sulfonyl/Sulfonamide Pyrimidines as Covalent Inhibitors of WRN Using a Multiplexed High-Throughput Screening Assay. Biochemistry. 2023 Jul 18;62(14):2147-2160. |