| Bioactivity | H-Ile-Lys-Val-Ala-Val-OH is one of the most potent active sites of laminin-1. H-Ile-Lys-Val-Ala-Val-OH promotes cell adhesion, neurite outgrowth, and tumor growth. H-Ile-Lys-Val-Ala-Val-OH stimulates BMMSC population growth and proliferation by activating MAPK/ERK1/2 and PI3K/Akt signalling pathways[1][2]. |
| Invitro | H-Ile-Lys-Val-Ala-Val-OH (0-2.5 mM, 0-48 h) 诱导骨髓间充质干细胞(BMMSC)增殖和增殖细胞核抗原(PCNA)合成[2]。H-Ile-Lys-Val-Ala-Val-OH (5 mM, 24 h) 诱导 BMMSC 细胞周期,使细胞从 G0/G1 进入 S 期并阻止它们进入 G2/M 期[2]。H-Ile-Lys-Val-Ala-Val-OH (0-2.5 mM, 0-48 h) 通过增强 BMMSCs 中 ERK1/2 和 Akt 的磷酸化水平激活 MAPK/ERK 和 PI3K/Akt 信号通路[2]。 Cell Proliferation Assay[2] Cell Line: |
| Name | H-Ile-Lys-Val-Ala-Val-OH |
| CAS | 131167-89-0 |
| Sequence | H-Ile-Lys-Val-Ala-Val-OH |
| Shortening | IKVAV |
| Formula | C25H48N6O6 |
| Molar Mass | 528.69 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |