Guanylyl Imidodiphosphate trisodium_product_DataBase

Bioactivity	Guanylyl Imidodiphosphate (Guanosine 5'-[β,γ-imido]triphosphate) trisodium is a non-hydrolysable GTP analogue, an activator of ADP-ribosylation factor (ARF) and a potent stimulator of adenylate cyclase. Imidodiphosphate trisodium can be used in protein synthesis studies[1][2][3].
Invitro	Guanylyl Imidodiphosphate trisodium (GppNHp) (100 μM) induces the secretion of dense granules from permeabilized platelets in response to calcium ion stimulation, and GTP-Ral enhances the calcium sensitivity of permeabilized platelet dense granule secretion which is inhibited by Sec5-RBD[1].Guanylyl Imidodiphosphate trisodium (GppNHp) (0.017-333 μM) causes a significant reduction in the lag time required to stimulate adenylate cyclase activity[3].
Name	Guanylyl Imidodiphosphate trisodium
CAS	148892-91-5
Formula	C10H17N6Na3O13P3
Molar Mass	591.16
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Mitsunori Kawato, et al. Regulation of platelet dense granule secretion by the Ral GTPase-exocyst pathway. J Biol Chem. 2008 Jan 4;283(1):166-174. [2]. J Goldberg, et al. Structural basis for activation of ARF GTPase: mechanisms of guanine nucleotide exchange and GTP-myristoyl switching. Cell. 1998 Oct 16;95(2):237-48. [3]. C Gaudin, et al. Overexpression of Gs alpha protein in the hearts of transgenic mice. J Clin Invest. 1995 Apr;95(4):1676-83.

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