| Bioactivity | Gramicidin A is a peptide component of gramicidin, an antibiotic mixture originally isolated from B. brevis. Gramicidin A is a highly hydrophobic channel-forming ionophore that forms channels in model membranes that are permeable to monovalent cations. Gramicidin A induces degradation of hypoxia inducible factor 1 α (HIF-1α)[1][2]. | ||||||
| Invitro | Gramicidin A displays potent broad-spectrum antibiotic activity against Gram-positive strains, even multidrug-resistant strains[1].Gramicidin A has the disadvantage of high hemolytic activity[1].Gramicidin A (0.1 nM-10 μM, 72 h) reduces the viability of RCC cell lines and affects cell viability comparable to Monensin (HY-N4302)[2].Gramicidin A cellular sensitivity is significantly altered by neither VHL nor HIF-1α expression[2].Gramicidin A (1 and 10 μM, 48 or 72 h) induces nonapoptotic cell death in RCC cells[2].Gramicidin A (0-10 μM, 24 h) depletes cellular energy and induces metabolic dysfunction in RCC cells[2].Gramicidin A (0-1 μM, 24-72 h) reduces HIF-1α and HIF-2α protein expression, reduces HIF transcriptional activity and target gene expression (24 h)[3] Cell Viability Assay[2] Cell Line: | ||||||
| Name | Gramicidin A | ||||||
| CAS | 11029-61-1 | ||||||
| Shortening | VGALAVVVWLWLWLWG | ||||||
| Formula | C99H140N20O17 | ||||||
| Molar Mass | 1882.29 | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Sealed storage, away from moisture
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
Gramicidin A
CAS: 11029-61-1 F: C99H140N20O17 W: 1882.29
Gramicidin A is a peptide component of gramicidin, an antibiotic mixture originally isolated from B. brevis. Gramicidin
Data collection：peptidedb@qq.com
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