| Bioactivity | GlyT1 Inhibitor 1 is a potent and selective GlyT1 inhibitor with an IC50 of 38 nM for rGlyT1[1]. Antipsychotic activity[1]. | ||||||||||||
| In Vivo | GlyT1 Inhibitor 1 (Compound 46) demonstrates in vivo efficacy in a rat novel object recognition (NOR) assay after oral dosing at 0.1, 1, and 3 mg/kg[1]. | ||||||||||||
| Name | GlyT1 Inhibitor 1 | ||||||||||||
| CAS | 1820934-93-7 | ||||||||||||
| Formula | C22H21N5O2 | ||||||||||||
| Molar Mass | 387.43 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Santora VJ, et al. Design and Synthesis of Novel and Selective Glycine Transporter-1 (GlyT1) Inhibitors with Memory Enhancing Properties. J Med Chem. 2018 Jul 26;61(14):6018-6033. |
GlyT1 Inhibitor 1
CAS: 1820934-93-7 F: C22H21N5O2 W: 387.43
GlyT1 Inhibitor 1 is a potent and selective GlyT1 inhibitor with an IC50 of 38 nM for rGlyT1. Antipsychotic activity.
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