Glutaminyl Cyclase Inhibitor 6_product_DataBase

Bioactivity	Glutaminyl Cyclase Inhibitor 6 (compound BI-43) is a secretory glutaminyl cyclase (sQC) and golgi-resident glutaminyl cyclase (gQC) inhibitor with IC50 values of 0.012 0.040 µM, respectively. Glutaminyl Cyclase Inhibitor 6 has the potential for the research of Parkinson’s disease[1].
Target	IC50: 0.012 µM (secretory glutaminyl cyclase (sQC)); 0.040 µM (golgi-resident glutaminyl cyclase (gQC))
In Vivo	Glutaminyl Cyclase Inhibitor 6 (compound BI-43) (10, 25, 40 mg/kg; i.p.; daily for 7 days) shows efficacy in alleviating MPTP (HY-15608)-induced motor dysfunctions across multiple behavioral performance tests[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
Formula	C27H23N5O3
Molar Mass	465.50
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Mou J, et al. X-ray Structure-Guided Discovery of a Potent Benzimidazole Glutaminyl Cyclase Inhibitor That Shows Activity in a Parkinson's Disease Mouse Model. J Med Chem. 2024 May 31.

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