| Bioactivity | Glutaminyl Cyclase Inhibitor 3 (compound 212 ), a designed anti-Alzheimer’s compound, is a potent human Glutaminyl Cyclase (GC) inhibitor, with an IC50 of 4.5 nM. Glutaminyl Cyclase-IN-1 (compound 212) significantly reduced the brain concentrations of pyroform Aβ and total Aβ and restored cognitive functions[1]. |
| Target | IC50: 4.5 nM (hGC). |
| Name | Glutaminyl Cyclase Inhibitor 3 |
| CAS | 2092921-50-9 |
| Formula | C24H32N6O2S |
| Molar Mass | 468.61 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Hoang VH, et al. Discovery of Potent Human Glutaminyl Cyclase Inhibitors as Anti-Alzheimer's Agents Based on Rational Design. J Med Chem. 2017 Mar 23;60(6):2573-2590. |
Glutaminyl Cyclase Inhibitor 3
CAS: 2092921-50-9 F: C24H32N6O2S W: 468.61
Glutaminyl Cyclase Inhibitor 3 (compound 212 ), a designed anti-Alzheimer’s compound, is a potent human Glutaminyl Cycl
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