| Bioactivity | Glucokinase activator 1 is a liver-directed glucokinase activator with an EC50 of 34 nM. |
| Target | EC50: 34 nM (Glucokinase) |
| In Vivo | Glucokinase activator 1 (3 to 300 mg/kg, oral, 180 minutes) shows a dose dependent improvement in glucose excursion in oGTT in a DIO mouse model of T2D. The predominant liver-directed tissue distribution of Glucokinase activator 1 ensures a good safety window with respect to hypoglycemia over a 10-fold dose range[1]. Animal Model: |
| Name | Glucokinase activator 1 |
| CAS | 1328987-85-4 |
| Formula | C27H20F2N2O7S2 |
| Molar Mass | 586.58 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Deshpande AM, et al. Discovery of liver-directed glucokinase activator having anti-hyperglycemic effect without hypoglycemia. Eur J Med Chem. 2017 Jun 16;133:268-286. |