| Bioactivity | Glucocorticoid receptor-IN-2 (Compound WX019) is a selective glucocorticoid receptor (GR) modulator with anti-inflammatory effect. Glucocorticoid receptor-IN-2 exhibits very good transcriptional repressive activity with an IC50 of 0.171 nM against hMMP1, and comparable transcriptional activation activity with an EC50 of 0.94 nM against MMTV[1]. |
| Invitro | Glucocorticoid receptor-IN-2 (Compound WX019) inhibits human peripheral blood mononuclear cells TNF-α with an IC50 of 0.98 nM[1].Glucocorticoid receptor-IN-2 shows inhibitory effect on CYP3A4 with an IC50 of 9.12 µM[1]. |
| Name | Glucocorticoid receptor-IN-2 |
| CAS | 2664932-65-2 |
| Formula | C25H20F4N6O2 |
| Molar Mass | 512.46 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Sheng Su, et al. Benzopyrazole compound. WO2021136429. |
Glucocorticoid receptor-IN-2
CAS: 2664932-65-2 F: C25H20F4N6O2 W: 512.46
Glucocorticoid receptor-IN-2 (Compound WX019) is a selective glucocorticoid receptor (GR) modulator with anti-inflammato
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