| Bioactivity | Glucagon receptor antagonists-7 (Compound 1) is an antagonist for hGCGR, that inhibits the binding of 125I-labeled glucagon to the human glucagon receptor (hGCGR) with IC50 of 181 nM. Glucagon receptor antagonists-7 activates glucagon-stimulated adenylyl cyclase with a KDB of 81 nM in CHO cell. Glucagon receptor antagonists-7 inhibits glucagon-mediated glycogenolysis in human hepatocytes, and lowers blood glucose levels[1]. |
| Target | IC50: human glucagon receptor (hGCGR) (181 nM) |
| CAS | 438618-32-7 |
| Formula | C20H30N2OS |
| Molar Mass | 346.53 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Qureshi SA, et al., A novel glucagon receptor antagonist inhibits glucagon-mediated biological effects. Diabetes. 2004 Dec;53(12):3267-73. |
Glucagon receptor antagonists-7
CAS: 438618-32-7 F: C20H30N2OS W: 346.53
Glucagon receptor antagonists-7 (Compound 1) is an antagonist for hGCGR, that inhibits the binding of 125I-labeled gluca
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