| Bioactivity | Glemanserin (MDL11939) is a potent and selective antagonist for serotonin receptor 5-HT2A (Ki=2.89, 0.54 and 2.5 nM for rat 5-HT2A, rabbit 5-HT2A and human 5-HT2A, respectively)[1][2]. | ||||||||||||
| In Vivo | Glemanserin (MDL11939) suppresses the induced increase in locomotor activity, behavioral sensitization and withdrawal symptoms in male mice[1]. | ||||||||||||
| Name | Glemanserin | ||||||||||||
| CAS | 107703-78-6 | ||||||||||||
| Formula | C20H25NO | ||||||||||||
| Molar Mass | 295.42 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Pehek EA, et al. Evidence for the preferential involvement of 5-HT2A serotonin receptors in stress- and drug-induced dopamine release in the rat medial prefrontal cortex. Neuropsychopharmacology. 2006;31(2):265-277. |
Glemanserin
CAS: 107703-78-6 F: C20H25NO W: 295.42
Glemanserin (MDL11939) is a potent and selective antagonist for serotonin receptor 5-HT2A (Ki=2.89, 0.54 and 2.5 nM for
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