Gepotidacin mesylate hydrate_product_DataBase

Bioactivity	Gepotidacin mesylate hydrate is an orally active triazaacenaphthylene antibiotic and bacterial type II topoisomerase inhibitor. Gepotidacin mesylate hydrate inhibits bacterial DNA replication by blocking topoisomerase enzymes. Gepotidacin mesylate hydrate selectively inhibits topoisomerase IV and the B subunit of DNA gyrase[1][2].
Invitro	Gepotidacin 是促旋酶催化的 DNA 超螺旋 (IC50 ≈ 0.047 μM) 和正超螺旋底物松弛 (IC50 ≈ 0.6 μM) 的强效抑制剂[1]。Gepotidacin 对 Mueller-Hinton 肉汤中 E. coli 分离株的 MIC 范围为 1 至 4 mg/L[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Gepotidacin mesylate hydrate 相关抗体:
CAS	1624306-20-2
Formula	C25H36N6O8S
Molar Mass	580.65
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Gibson EG, et al. Mechanistic and Structural Basis for the Actions of the Antibacterial Gepotidacin against Staphylococcus aureus Gyrase. ACS Infect Dis. 2019 Apr 12;5(4):570-581. [2]. Watkins RR, et al. Gepotidacin: a novel, oral, 'first-in-class' triazaacenaphthylene antibiotic for the treatment of uncomplicated urinary tract infections and urogenital gonorrhoea. J Antimicrob Chemother. 2023 May 3;78(5):1137-1142.

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