| Bioactivity | Gcase activator 2 (compound 14), a pyrrolo[2,3-b]pyrazine, is alos a β-Glucocerebrosidase (GCase) activator (EC50=3.8 μM). Gcase activator 2 induces GCase dimerizatio (both K-type and V-type). And Gcase activator 2 has low metabolic clearance in human and mouse[1]. | ||||||||||||
| Target | β-Glucocerebrosidase | ||||||||||||
| Invitro | Gcase activator 2 在人和小鼠体内具有较低的代谢清除率，CL 值分别为 10 和 12 μL/min/mg[1]。 | ||||||||||||
| Name | Gcase activator 2 | ||||||||||||
| CAS | 2759897-35-1 | ||||||||||||
| Formula | C21H24N4O2 | ||||||||||||
| Molar Mass | 364.44 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Benz J, et al. Novel β-Glucocerebrosidase Activators That Bind to a New Pocket at a Dimer Interface and Induce Dimerization. Angew Chem Int Ed Engl. 2021 Mar 1;60(10):5436-5442. |
Gcase activator 2
CAS: 2759897-35-1 F: C21H24N4O2 W: 364.44
Gcase activator 2 (compound 14), a pyrrolopyrazine, is alos a β-Glucocerebrosidase (GCase) activator (EC50=3.8 μM). Gc
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