| Bioactivity | Ganoderic acid Mk (GA-Mk) is a triterpenoid acid, that can be isolated from the mycelia of Ganoderma lucidum. Ganoderic acid Mk is efficiently anti-proliferative and can induce apoptosis of HeLa cells by mitochondria-mediated pathway. Ganoderic acid Mk can be used for cervical cancer research[1][2]. |
| Invitro | Ganoderic acid Mk (0-100 μM, 24 h) 对人类癌细胞表现出比人类正常细胞系更强的细胞毒性[1]。Ganoderic acid Mk (0-40 μM, 12-48 h) 对HeLa细胞增殖具有剂量依赖性抑制作用[1]。Ganoderic acid Mk (0-40 μM, 24 h) 诱导HeLa细胞凋亡[1]。Ganoderic acid Mk (0-40 μM, 24 h) 诱导 ROS 爆发，MMP 减少和 caspase-3, -9 活性增加[1]。 Cell Cytotoxicity Assay[1] Cell Line: |
| Name | Ganoderic acid Mk |
| CAS | 110024-14-1 |
| Formula | C34H50O7 |
| Molar Mass | 570.76 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Liu R M, et al. Anti-proliferation and induced mitochondria-mediated apoptosis of ganoderic acid Mk from Ganoderma lucidum mycelia in cervical cancer HeLa cells[J]. Latin American Journal of Pharmacy, 2012, 31(1):43-50. [2]. Ding N, et al. Separation and determination of four ganoderic acids from dried fermentation mycelia powder of Ganoderma lucidum by capillary zone electrophoresis. J Pharm Biomed Anal. 2010 Dec 15;53(5):1224-30. |
Ganoderic acid Mk
CAS: 110024-14-1 F: C34H50O7 W: 570.76
Ganoderic acid Mk (GA-Mk) is a triterpenoid acid, that can be isolated from the mycelia of Ganoderma lucidum. Ganoderic
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