Gangliotetraose_product_DataBase

Bioactivity	Gangliotetraose (Gg4) is a tetrasccharide, exhibits major components including GM1 and its sialylated derivatives. GM1 facilitates efflux of nuclear Ca2+ and reduces the level of nuclear Ca2+ that characterizes the differentiated neuron. GM1 affects neuronal plasticity and repair mechanisms, as well as neurotrophin release in the brain[1][2].
Invitro	Gangliotetraose (GM1) (10 μM; 1 h) increases the viability of pheochromocytoma PC12 cells exposed to hydrogen peroxide (1 mM; 2 h) and diminishes the accumulation of reactive oxygen species and oxidative inactivation of Na+, K+-ATPase[3]. Gangliotetraose (GM1) (100 nM and 10 μM; ) increases the basal activity of Akt and ERK1/2, without changing Akt activity in PC12 cells exposed to hydrogen peroxide[3].Gangliotetraose (GM1) (50 μM; 24 h) binds the midportion of Aβ to produce Aβ oligomers, GM1 bound Aβ (GAβ). GAβ is endogenously generated in the brain and accelerates Aβ assembly by acting as a seed[4]. Cell Viability Assay[3] Cell Line:
Name	Gangliotetraose
CAS	75645-24-8
Formula	C26H45NO21
Molar Mass	707.63
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.

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