Gambogic amide_product_DataBase

Bioactivity	Gambogic amide is a potent and selective agonist of TrkA and also induces its tyrosine phosphorylation and activation of downstream signaling, including Akt and MAPK. Gambogic amide specifically interacts with the cytoplasmic juxtamembrane domain of the TrkA receptor and triggers its dimerization, leading to activation. Gambogic amide has neuroprotective activity preventing glutamate-induced neuronal cell death. Gambogic amide has improved efficacy in a transient middle cerebral artery occlusion model of stroke and could be used to study neurodegenerative diseases and stroke[1].
Invitro	Gambogic amide（0.5 μM；30 分钟）可引发海马神经元中的 TrkA 酪氨酸磷酸化[1]。 0 --> Gambogic amide 相关抗体: Western Blot Analysis[1] Cell Line:
In Vivo	Gambogic amide（2 mg/kg；皮下注射；单剂量）可防止 MCAO 动物模型中的神经细胞死亡并减少梗塞体积[1]。 Animal Model:
Name	Gambogic amide
CAS	286935-60-2
Formula	C38H45NO7
Molar Mass	627.77
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Jang SW, et al. Gambogic amide, a selective agonist for TrkA receptor that possesses robust neurotrophic activity, prevents neuronal cell death. Proc Natl Acad Sci U S A. 2007 Oct 9;104(41):16329-34.

PeptideDB