| Bioactivity | Galantide, a non-specific galanin receptor antagonist, is a peptide consisting of fragments of galanin and substance P. Galantide recognizes two classes of galanin binding sites (KD<0.1 nM and ~6 nM) in the rat hypothalamus. Galantide dose dependently (IC50=1.0 nM) antagonizes the galanin-mediated inhibition of the glucose-induced insulin secretion from mouse pancreatic islets. Galantide appears to bind to a single population of SP receptors (KD~40 nM)[1][2][3]. | ||||||
| Invitro | Galantide do not activate the K+ conductance but produces a concentration-dependent antagonism (IC50=4 nM) of the galanin-induced increase in K+ conductance. Galantide acts like galanin and inhibits the voltage-dependent Ba2+ current (IBa). The inhibition of IBa also is concentration dependent (IC50=16 nM) and the maximum inhibition produced by galantide is approximately 40%[3]. | ||||||
| Name | Galantide | ||||||
| CAS | 138579-66-5 | ||||||
| Sequence | Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 | ||||||
| Shortening | GWTLNSAGYLLGPQQFFGLM-NH2 | ||||||
| Formula | C104H151N25O26S | ||||||
| Molar Mass | 2199.53 | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Sealed storage, away from moisture
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
Galantide
CAS: 138579-66-5 F: C104H151N25O26S W: 2199.53
Galantide, a non-specific galanin receptor antagonist, is a peptide consisting of fragments of galanin and substance P.
Data collection：peptidedb@qq.com
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