| Bioactivity | Galanthamine is a potent acetylcholinesterase (AChE) inhibitor with an IC50 of 500 nM. | ||||||||||||
| Invitro | Galanthamine inhibits AChE and BChE with IC50 of 0.5 and 8.5 μM[1]. Galanthamine acts as a positive allosteric modulator (PAM) of human α4β2 AChRs expressed in permanently transfected HEK 293 cells. Galanthamine increases the response of (α4β2)2α5 AChRs to 1 μM ACh by up to 220% with very low concerntration(EC50=0.25 nM). Only small potentiation (20%) of either α4β2 or (α4β2)2β3 AChRs is detected using FLEXstation assays. Galanthamine at concentrations of 1 μM and above inhibits all three AChR subtypes[2]. | ||||||||||||
| Name | Galanthamine | ||||||||||||
| CAS | 357-70-0 | ||||||||||||
| Formula | C17H21NO3 | ||||||||||||
| Molar Mass | 287.35 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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