| Bioactivity | GX-936 (PF-05196233), a potent and Nav1.7-subtype selective inhibitor, binds to the activated state of voltage-sensor domain IV (VSD4)[1][2][3]. |
| CAS | 1235406-09-3 |
| Formula | C24H20F3N7O3S2 |
| Molar Mass | 575.59 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. R Ian Storer, et al. Highly potent and selective NaV1.7 inhibitors for use as intravenous agents and chemical probes. Bioorg Med Chem Lett. 2017 Nov 1;27(21):4805-4811. [2]. Shivani Ahuja, et al. Structural basis of Nav1.7 inhibition by an isoform-selective small-molecule antagonist. Science. 2015 Dec 18;350(6267):aac5464. [3]. Jian Payandeh, et al. Selective Ligands and Drug Discovery Targeting the Voltage-Gated Sodium Channel Nav1.7. Handb Exp Pharmacol. 2018:246:271-306. |
GX-936
CAS: 1235406-09-3 F: C24H20F3N7O3S2 W: 575.59
GX-936 (PF-05196233), a potent and Nav1.7-subtype selective inhibitor, binds to the activated state of voltage-sensor do
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.