GW837016X_product_DataBase

Bioactivity	GW837016X (NEU-391) is an orally active ErbB-2 kinase covalent inhibitor. GW837016X also is a potent antitrypanosome agent. GW837016X inhibits mitosis and cytokinesis[1].
Invitro	GW837016X 可抑制 Trypanosoma brucei 的增殖，IC50 值为 0.4 µM[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> GW837016X 相关抗体:
In Vivo	GW837016X (130 mg/kg; p.o.; daily for 10 days) 可抑制 Trypanosoma brucei 增殖并提高 Trypanosoma brucei 感染小鼠的平均存活率[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
CAS	833473-68-0
Formula	C25H20ClFN4OS
Molar Mass	478.97
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Woodring JL, et al. Series of Alkynyl-Substituted Thienopyrimidines as Inhibitors of Protozoan Parasite Proliferation. ACS Med Chem Lett. 2018 Sep 4;9(10):996-1001.

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