| Bioactivity | GW284543 (UNC10225170) hydrochloride is a selective MEK5 inhibitor. GW284543 reduces pERK5, and decreases endogenous MYC protein[1]. |
| Invitro | GW284543 (10 and 20 μM; 6 h) treatment inhibits MEK5 in a dose-dependent manner and reduces pERK5[1]. Western Blot Analysis[1] Cell Line: |
| Name | GW284543 hydrochloride |
| CAS | 179246-08-3 |
| Formula | C23H21ClN2O3 |
| Molar Mass | 408.88 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Vaseva AV, et al. KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism. Cancer Cell. 2018 Nov 12;34(5):807-822.e7. |
GW284543 hydrochloride
CAS: 179246-08-3 F: C23H21ClN2O3 W: 408.88
GW284543 (UNC10225170) hydrochloride is a selective MEK5 inhibitor. GW284543 reduces pERK5, and decreases endogenous MYC
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.