| Bioactivity | GV-150013 is a selective CCK-B receptor antagonist. GV-150013 has sleep aid effect[1]. |
| Target | CCK-B |
| In Vivo | GV-150013 (0.5 - 60μg/kg, 静脉注射, 给药一次) 在老年大鼠模型中增加快速动眼睡眠和非快速动眼睡眠[1]. Animal Model: |
| Name | GV-150013 |
| CAS | 167355-22-8 |
| Formula | C33H34N4O3 |
| Molar Mass | 534.65 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Crespi F. Cholecystokinin-B (CCK-B) receptor antagonists improve "aged" sleep: a new class of sleep modulators? Methods Find Exp Clin Pharmacol. 1999 Jan-Feb;21(1):31-8. [2]. F.Crespi, et al. Influence of cholecystokinin-B (CCK-B) receptor antagonists on rat electroencephalography (EEG): A new class of sleep modulators? Gaviraghi. Dept of Pharmacology GlaxoWellcome S.p.A., Medicine Research Centre, via A. Fleming, 4, 37135 Verona, Italy |