| Bioactivity | GUB03385 is a long-acting PrRP31 analogue. GUB03385 is a potent dual agonist for GPR10 (full agonist, EC50: 0.4 nM) and NPFF2R (partial agonist, EC50: 20 nM). GUB03385 has anti-obesity effect[1]. |
| Sequence | Ser-Arg-Thr-His-Arg-His-Ser-Met-Glu-Ile-Arg-Thr-Pro-Asp-Ile-Asn-Pro-Ala-Trp-Tyr-Ala-Ser-Arg-Gly-{Lys(OEG-OEG-gGlu-C18)}-Arg-Pro-Val-Gly-Arg-Phe-NH2 |
| Shortening | SRTHRHSMEIRTPDINPAWYASRG-{Lys(OEG-OEG-gGlu-C18)}-RPVGRF-NH2 |
| Formula | C198H322N60O52S |
| Molar Mass | 4407.11 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Alexopoulou F, et al. Lipidated PrRP31 metabolites are long acting dual GPR10 and NPFF2 receptor agonists with potent body weight lowering effect. Sci Rep. 2022 Feb 1;12(1):1696. |