| Bioactivity | GTSE1-IN-1 (compound Y18) is an orally active GTSE1 inhibitor with anticancer activity. GTSE1-IN-1 significantly inhibits cancer cell proliferation by inhibiting the transcription and expression of GTSE1, causing DNA damage and persistently inducing cell cycle arrest and cell senescence. In addition, GTSE1-IN-1 significantly inhibits the adhesion, migration and invasion of colorectal cancer HCT116 cells and non-small cell lung cancer A549 cells in vitro[1]. |
| CAS | 3002034-34-3 |
| Formula | C21H24FN7 |
| Molar Mass | 393.46 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Sunhui Xing, et al. "Discovery of pyrimidine-2, 4-diamine analogues as efficiency anticancer drug by targeting GTSE1." Bioorganic Chemistry (2024): 107700. |
GTSE1-IN-1
CAS: 3002034-34-3 F: C21H24FN7 W: 393.46
GTSE1-IN-1 (compound Y18) is an orally active GTSE1 inhibitor with anticancer activity. GTSE1-IN-1 significantly inhibit
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