| Bioactivity | GSK_WRN3 is a selective inhibitor of WRN protease (IC50 = 8.6 μM). GSK_WRN3 displays a high degree of selectivity by forming a covalent binding to the Cys727 residue of the WRN protein. GSK_WRN3 reduces growth support for MSI tumor cells by inhibiting WRN protease activity, resulting in increased DNA double-strand breaks and cell growth inhibition[1]. |
| CAS | 2923009-50-9 |
| Formula | C16H20N2O5S |
| Molar Mass | 352.41 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Picco G, et al. Novel WRN Helicase Inhibitors Selectively Target Microsatellite Unstable Cancer Cells. Cancer Discov. 2024 Apr 9. |
GSK_WRN3
CAS: 2923009-50-9 F: C16H20N2O5S W: 352.41
GSK_WRN3 is a selective inhibitor of WRN protease (IC50 = 8.6 μM). GSK_WRN3 displays a high degree of selectivity by fo
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.