| Bioactivity | GSK621 is a specific AMPK activator, with IC50 values of 13-30 μM for AML cells. GSK621 induces autophagy and apoptosis. GSK621 induces eiF2α phosphorylation-a hallmark of UPR activation[1]. | ||||||||||||
| Invitro | GSK621 (30 μM) induces AMPKα T172, ACC (S79) and ULK1 (S555) phosphorylation[1].GSK621 (30 μM) induces autophagy and apoptosis[1].GSK621 treatment also induces PERK phosphorylation, a marker of ER stress, in AML cells[1]. Cell Proliferation Assay[1] Cell Line: | ||||||||||||
| Name | GSK621 | ||||||||||||
| CAS | 1346607-05-3 | ||||||||||||
| Formula | C26H20ClN3O5 | ||||||||||||
| Molar Mass | 489.91 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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