| Bioactivity | GSK2647544 is an orally available, selective inhibitor of Lp-PLA2. Lipoprotein-associated phospholipase (Lp-PLA2) is a calcium-independent phospholipase A2 with proinflammatory activities that is primarily secreted by monocyte-derived macrophages[1]. |
| Name | GSK2647544 |
| CAS | 1380426-95-8 |
| Formula | C24H18ClF3N4O3 |
| Molar Mass | 502.87 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
| Reference | [1]. Wu K, et al. Evaluation of the safety, pharmacokinetics, pharmacodynamics, and drug-drug interaction potential of a selective Lp-PLA2 inhibitor (GSK2647544) in healthy volunteers . Int J Clin Pharmacol Ther. 2016;54(12):935-949. |
GSK2647544
CAS: 1380426-95-8 F: C24H18ClF3N4O3 W: 502.87
GSK2647544 is an orally available, selective inhibitor of Lp-PLA2. Lipoprotein-associated phospholipase (Lp-PLA2) is a c
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