| Bioactivity | GSK2018682 is an agonist for S1P1 and S1P5 receptor with pEC50s of 7.7 and 7.2, respectively, and has no agonist activity towards human S1P2, S1P3, or S1P4. GSK2018682 is used in the research of multiple sclerosis. | ||||||||||||
| Target | pEC50: 7.7 (S1P1 receptor), 7.2 (S1P5 receptor) | ||||||||||||
| Invitro | GSK2018682 is an agonist for S1P1 and S1P5 receptor with pEC50s of 7.7 and 7.2, respectively, and has no agonist activity towards human S1P2, S1P3, or S1P4[1]. | ||||||||||||
| Name | GSK2018682 | ||||||||||||
| CAS | 1034688-30-6 | ||||||||||||
| Formula | C22H21ClN4O4 | ||||||||||||
| Molar Mass | 440.88 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Xu J, et al. Safety, pharmacokinetics, pharmacodynamics, and bioavailability of GSK2018682, a sphingosine-1-phosphate receptor modulator, in healthy volunteers. Clin Pharmacol Drug Dev. 2014 May;3(3):170-8. |
GSK2018682
CAS: 1034688-30-6 F: C22H21ClN4O4 W: 440.88
GSK2018682 is an agonist for S1P1 and S1P5 receptor with pEC50s of 7.7 and 7.2, respectively, and has no agonist activit
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