GSK-3β inhibitor 8_product_DataBase

Bioactivity	GSK-3β inhibitor 8, a thiophenacil derivative, is an effective and selective inhibitor of GSK-3β (IC50=64 nM). GSK-3β inhibitor 8 negatively regulated Wnt signaling pathway and stimulated β cell proliferation[1][2].
Invitro	GSK-3β inhibitor 8 (化合物 1a) (1 nM-100 μM; 7 d) 剂量依赖性地刺激 β 细胞增殖，EC50 值为 1.41 μM。GSK-3β inhibitor 8 (2 μM; 72 h) 使复制 R7T1 β 细胞增加约 2 倍[1]。GSK-3β inhibitor 8 (1 nM-100 μM; 24 h) 诱导 Super (8X) TOPFlash 报告晶活化，EC50 值为 1.25 μM[1]。GSK-3β inhibitor 8 (2 μM; 72 h) 刺激 HEK293 细胞 β-catenin 转位进入细胞核[1]。
Name	GSK-3β inhibitor 8
CAS	1139875-74-3
Formula	C20H20ClN5OS
Molar Mass	413.92
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Wang W, et al. Identification of small-molecule inducers of pancreatic beta-cell expansion. Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1427-32.

PeptideDB