| Bioactivity | GSK-3 inhibitor 1 (compound core 3) is a GSK-3 inhibitor that induces stem/progenitor cell self-renewal (e.g. induces stem/progenitor cell proliferation while maintaining the ability to differentiate into tissue cells in the progeny)[1][2]. |
| Invitro | GSK-3 inhibitor 1 can be used to induce, promote or enhance the growth, proliferation or regeneration of inner ear tissues such as inner ear supporting cells or inner ear hair cells[2]. |
| Name | GSK-3 inhibitor 1 |
| CAS | 603272-51-1 |
| Formula | C22H17ClFN5O2 |
| Molar Mass | 437.85 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
| Reference | [1]. SOLUBILIZED COMPOSITIONS FOR CONTROLLED PROLIFERATION OF STEM CELLS / GENERATING INNER EAR HAIR CELLS USING GSK3 INHIBITORS: III. 20170252449 A1 [2]. Christopher Loose, et al. 1h-pyrrole-2,5-dione compounds and methods of using them to induce self-renewal of stem/progenitor supporting cells. Patent WO2018125746A1. |
GSK-3 inhibitor 1
CAS: 603272-51-1 F: C22H17ClFN5O2 W: 437.85
GSK-3 inhibitor 1 (compound core 3) is a GSK-3 inhibitor that induces stem/progenitor cell self-renewal (e.g. induces st
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