| Bioactivity | GSK-1482160 is an orally available negative allosteric modulator of the P2X7 receptor. P2X7 receptors are involved in the production of pro-inflammatory cytokines, such as Il-1β, by central and peripheral immune cells. GSK-1482160 has the potential for the research of inflammation diseases[1]. | ||||||||||||
| Name | GSK-1482160 | ||||||||||||
| CAS | 1001389-72-5 | ||||||||||||
| Formula | C14H14ClF3N2O2 | ||||||||||||
| Molar Mass | 334.72 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Ali Z, et al. Pharmacokinetic and pharmacodynamic profiling of a P2X7 receptor allosteric modulator GSK1482160 in healthy human subjects. Br J Clin Pharmacol. 2013;75(1):197-207. doi:10.1111/j.1365-2125.2012.04320.x |
GSK-1482160
CAS: 1001389-72-5 F: C14H14ClF3N2O2 W: 334.72
GSK-1482160 is an orally available negative allosteric modulator of the P2X7 receptor. P2X7 receptors are involved in th
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