| Bioactivity | GS-441524 hydrochloride, predominant metabolite of Remdesivir and superior to Remdesivir against Covid-19 , shows comparable efficacy in cell-based models of primary human lung and cat cells infected with coronavirus. GS-441524 hydrochloride could strongly inhibits feline infectious peritonitis virus (FIPV), with an EC50 of 0.78 μM[1][2][3]. |
| CAS | 2378280-82-9 |
| Formula | C12H14ClN5O4 |
| Molar Mass | 327.72 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Murphy BG, et al. The nucleoside analog GS-441524 strongly inhibits feline infectious peritonitis (FIP) virus in tissue culture and experimental cat infection studies. Vet Microbiol. 2018 Jun;219:226-233. [2]. Katherine Yang, et al. What Do We Know About Remdesivir Drug Interactions? Clin Transl Sci. 2020 May 13;10.1111/cts.12815. [3]. Victoria C. Yan, et al. Advantages of the Parent Nucleoside GS-441524 over Remdesivir for Covid-19 Treatment. ACS Med. Chem. Lett. 2020. |
GS-441524 hydrochloride
CAS: 2378280-82-9 F: C12H14ClN5O4 W: 327.72
GS-441524 hydrochloride, predominant metabolite ofRemdesivir and superior to Remdesivir against Covid-19 , shows compara
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