| Bioactivity | GRP75-IN-1 hydrochloride (compound 33) is an anti-endometrial cancer (EC) agent that induces apoptosis. GRP75-IN-1 hydrochloride reduces Ca2+ levels in mitochondria by targeting GRP75 and disrupting its interaction with IP3R[1]. |
| Formula | C27H39ClN4OS |
| Molar Mass | 503.14 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ling X, et al. Discovery of Novel Azaphenothiazine Derivatives to Suppress Endometrial Cancer by Targeting GRP75 to Impair Its Interaction with IP3R and Mitochondrial Ca2+ Homeostasis. J Med Chem. 2024 Jul 31. |