| Bioactivity | GRL-0496 is a potent chloropyridyl ester-derived SARS-CoV 3CLpro inhibitor, with an IC50 of 30 nM in both enzyme inhibitory and antiviral assays. GRL-0496 shows SARS-CoV antiviral activity, with an EC50 of 6.9 μM[1]. | ||||||||||||
| Target | IC50: 30 nM (SARS-CoV 3CLpro) | ||||||||||||
| Invitro | GRL-0496 shows the best SARS-CoV antiviral activity, with an EC EC50 of 6.9 μM[1]. | ||||||||||||
| Name | GRL-0496 | ||||||||||||
| CAS | 1087243-14-8 | ||||||||||||
| Formula | C14H9ClN2O2 | ||||||||||||
| Molar Mass | 272.69 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Ghosh AK, et, al. Design, synthesis and antiviral efficacy of a series of potent chloropyridyl ester-derived SARS-CoV 3CLpro inhibitors. Bioorg Med Chem Lett. 2008 Oct 15;18(20):5684-8. |
GRL-0496
CAS: 1087243-14-8 F: C14H9ClN2O2 W: 272.69
GRL-0496 is a potent chloropyridyl ester-derived SARS-CoV 3CLpro inhibitor, with an IC50 of 30 nM in both enzyme inhibit
Data collection：peptidedb@qq.com
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