| Bioactivity | GR 89696 is a highly selective κ2 opioid receptor agonist with potential to prevent pruritus[1]. |
| In Vivo | GR 89696 (intramuscular injection, 0.01-0.1 μg/kg) 可以以一种剂量依赖的方式减轻鞘内注射吗啡（0.03mg)诱导的抓挠反应而不影响吗啡镇痛作用[1]。GR-896960(subcutaneous injection, 1 mg/kg) 在大鼠永久性局灶性缺血模型中，使大脑动脉梗塞体积减少了 38%[2]。 |
| Name | GR 89696 |
| CAS | 126766-32-3 |
| Formula | C23H29Cl2N3O7 |
| Molar Mass | 530.40 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Mei-Chuan Ko, et al. Effects of atypical kappa-opioid receptor agonists on intrathecal morphine-induced itch and analgesia in primates. J Pharmacol Exp Ther. 2009 Jan;328(1):193-200. [2]. A Barber, et al. Effects of GR-89696 and the novel peripherally selective OP2 agonists, EMD-61569 and EMD-61747, against focal cerebral ischemia in the rat. Methods Find Exp Clin Pharmacol. 1999 Mar;21(2):105-13 |