| Bioactivity | GR 89696 free base is a highly selective κ2 opioid receptor agonist with potential to prevent pruritus[1]. |
| In Vivo | GR 89696 free base (肌内注射, 0.01-0.1 μg/kg) 剂量依赖性减弱鞘内注射吗啡 (0.03 mg) 诱导的抓挠反应而不影响吗啡的镇痛作用[1]。GR-896960 free base (皮下注射，1 mg/kg) 在永久性局灶性缺血大鼠模型中将脑动脉梗塞体积减少 38%[2]。 |
| Name | GR 89696 free base |
| CAS | 126766-31-2 |
| Formula | C19H25Cl2N3O3 |
| Molar Mass | 414.33 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Mei-Chuan Ko, et al. Effects of atypical kappa-opioid receptor agonists on intrathecal morphine-induced itch and analgesia in primates. J Pharmacol Exp Ther. 2009 Jan;328(1):193-200. [2]. A Barber, et al. Effects of GR-89696 and the novel peripherally selective OP2 agonists, EMD-61569 and EMD-61747, against focal cerebral ischemia in the rat. Methods Find Exp Clin Pharmacol. 1999 Mar;21(2):105-13 |