| Bioactivity | GR 83074 is a potent and selective NK-2 (Neurokinin Receptor) antagonist with a pKB of 8.23. GR 83074 is inactive as an NK-3 antagonist and exhibits a 340-fold NK-2/NK-1 selectivity[1]. |
| Invitro | In the isolated rat colon and guinea-pig trachea, GR 83074 is a potent competitive antagonist of the contractions induced by the selective NK-2 agonist GR6434[1]. |
| Name | GR 83074 |
| CAS | 141636-44-4 |
| Shortening | {Boc}-AA-{D-Trp}-F-{D-Pro}-P-{Nle}-NH2 |
| Formula | C50H72N12O9 |
| Molar Mass | 985.18 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |