| Bioactivity | GR 103691 is a potent, selective dopamine D3 receptor antagonist with a Ki value of 0.4 nM. GR 103691 shows more than 100-fold selectivity for human dopamine human (h)D3 over hD4 and hD1 sites[1]. | |||||||||
| Target | Ki: 0.4 nM (Human dopamine D3 receptor) | |||||||||
| Invitro | GR 103691 shows marked affinity for serotonin1A (5-HT1A) receptors (Ki of 5.8 nM) and α-1 adrenoceptors (Ki of 12.6 nM)[1]. | |||||||||
| Name | GR 103691 | |||||||||
| CAS | 162408-66-4 | |||||||||
| Formula | C30H35N3O3 | |||||||||
| Molar Mass | 485.62 | |||||||||
| Appearance | Solid | |||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
| Storage |
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| Reference | [1]. Audinot V, et al. A comparative in vitro and in vivo pharmacological characterization of the novel dopamine D3 receptor antagonists (+)-S 14297, nafadotride, GR 103,691 and U 99194. J Pharmacol Exp Ther. 1998 Oct;287(1):187-97. |
GR 103691
CAS: 162408-66-4 F: C30H35N3O3 W: 485.62
GR 103691 is a potent, selective dopamine D3 receptor antagonist with a Ki value of 0.4 nM. GR 103691 shows more than 10
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