| Bioactivity | GQN-B37-Me is a MCL-1 inhibitor. GQN-B37-Me induces caspase-dependent apoptosis. GQN-B37-Me exhibits noteworthy cytotoxicity in H929 (IC50 = 3.71 μM) and MV-4-11 (IC50 = 5.57 μM) cells. GQN-B37-Me can be used for the research of leukemia[1]. |
| Target | MCL-1 |
| Invitro | GQN-B37-Me (1-20 μM, 24 h) 以明显的剂量依赖性方式诱导 MV-4-11 细胞晚期凋亡[1]。GQN-B37-Me (10-40 μM, 10 h) 能够阻断 H929 细胞中的 MCL-1/BIM 相互作用，从而诱导 caspase 依赖性凋亡[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> GQN-B37-Me 相关抗体: |
| In Vivo | GQN-B37-Me (12.5-50 mg/kg，腹腔注射，20 天内每 2 天一次) 可减小 MV-4-11 异种移植小鼠白血病模型中的肿瘤体积[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| Formula | C30H25ClN4O4 |
| Molar Mass | 541.00 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Gong Q, et al. Discovery of Phenylpyrazole Derivatives as a New Class of Selective Inhibitors of MCL-1 with Antitumor Activity. ACS Omega. 2024 Jun 13;9(25):27369-27396. |